AFF3
Sign in to saveAlso known as LAF4, MLLT2-like, AF4/FMR2 family member 3, KINS
AF4/FMR2 family member 3 is a protein that in humans is encoded by the AFF3 gene.
In the Vinony graph
Within Vinony's link graph, AFF3 is referenced by 5 other articles, and connects out to PubMed, human chromosome 2 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 2.
Its subject is documented across 5 Wikipedia language editions.
Gene data
AFF3- Name
- ALF transcription elongation factor 3
- Type
- protein-coding
- Position
- 99,545,419–100,192,469 (−)
- Aliases
- KINS, LAF4, MLLT2-like
- Ensembl
- ENSG00000144218
- RefSeq RNA
- NM_001025108.2, NM_001386135.1, NM_002285.3, XM_005263943.5, XM_005263945.5
- RefSeq protein
- NP_001020279.1, NP_001373064.1, NP_002276.2, XP_005264000.2, XP_005264002.1
This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Gene · Ensembl
ALF transcription elongation factor 3
- Symbol
- AFF3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:99,545,419-100,192,469
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 1718
- genomic start
- 99545419
- genetic association
- type-1 diabetes
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3899
- genomic end
- 100192428
- chromosome
- human chromosome 2
- cytogenetic location
- 2q11.2
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- References
- External links
- Further reading
AF4/FMR2 family member 3 is a protein that in humans is encoded by the AFF3 gene.
== Function ==
Excerpted from Wikipedia’s “AFF3” article, available under the CC BY-SA 4.0 licence.