TRIOBP

Also known as DFNB28, TAP68, TARA, dJ37E16.4, HRIHFB2122, TRIO and F-actin binding protein

TRIO and F-actin-binding protein is a protein that in humans is encoded by the TRIOBP gene.

Gene data

TRIOBP

Name: TRIO and F-actin binding protein
Type: protein-coding
Aliases: DFNB28, HRIHFB2122, TAP68, TARA, dJ37E16.4

This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008].

via MyGene.info

Gene · Ensembl

TRIO and F-actin binding protein

Symbol: TRIOBP
Biotype: Protein coding
Organism: Homo sapiens
Location: 22:37,696,983-37,776,581
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

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HomoloGene ID: 5104
exact match: identifiers.org/ncbigene/11078
genomic end: 38172563
genomic start: 37697048
cytogenetic location: 22q13.1

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TRIO and F-actin-binding protein is a protein that in humans is encoded by the TRIOBP gene.

This gene encodes a protein that interacts with Trio, which is involved with neural tissue development and in controlling actin cytoskeleton organization, cell motility, and cell growth. This trio-binding protein also associates with F-actin and stabilizes F-actin structures. Domains contained in this encoded protein are an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. Mutations in this gene have been associated with a form of autosomal-recessive nonsyndromic deafness. Multiple alternatively-spliced transcript variants that would encode different isoforms have been found for this gene, though some transcripts may be subject to nonsense-mediated decay (NMD).