dynein
Sign in to saveAlso known as dyneins
thumbnail|right|Cytoplasmic dynein on a microtubule Dyneins are a family of cytoskeletal motor proteins (though they are actually protein complexes) that move along microfilaments in cells. They convert the chemical energy stored in ATP to mechanical work. Dynein transports various cellular cargos, provides forces and displacements important in mitosis, and drives the beat of eukaryotic cilia and flagella. All of these functions rely on dynein's ability to move towards the minus-end of the microtubules, known as retrograde transport; thus, they are called "minus-end directed motors". In contra
Key facts
- Protein family.Symbol
- Robl1, Robl2
- Protein family.Name
- Roadblock
- Protein family.Pfam
- PF03259
- Protein family.InterPro
- IPR016561
- Protein family.caption
- Structure of Roadblock/LC7 protein - RCSB PDB 1y4o
- Protein family.Pfam_clan
- CL0023
- Protein family.PDB
- http://www.rcsb.org/pdb/explore/explore.do?structureId=4w7g
- Protein family.image
- Roadblock protein RCSB PDB 1y4o screenshot.png
- Protein family.PROSITE
- PDOC00953
- Protein family.SCOP
- 1y4o
via Wikipedia infobox
Research
8,492 papers- Dynein at the kinetochore.Journal of cell science · 2023
- Molecular mechanism of dynein-dynactin complex assembly by LIS1.Science (New York, N.Y.) · 2024
- Cytoplasmic dynein-2 at a glance.Journal of cell science · 2020
- Structure and Function of Dynein's Non-Catalytic Subunits.Cells · 2024
- Structure and Mechanics of Dynein Motors.Annual review of biophysics · 2021
via PubMed
Wikidata facts
Show 2 more facts
- EC enzyme number
- 5.6.1.2
- Commons category
- Dyneins
Sources (2)
via Wikidata · CC0
~12 min read
Encyclopedic overview
13 sectionsContents
- Classification
- Function
- Mitotic spindle positioning
- Viral replication
- Structure
- Cytoplasmic dynein
- Axonemal dynein
- History
- Chromosome segregation during meiosis
- See also
- References
- Further reading
- External links
thumbnail|right|Cytoplasmic dynein on a microtubule Dyneins are a family of cytoskeletal motor proteins (though they are actually protein complexes) that move along microfilaments in cells. They convert the chemical energy stored in ATP to mechanical work. Dynein transports various cellular cargos, provides forces and displacements important in mitosis, and drives the beat of eukaryotic cilia and flagella. All of these functions rely on dynein's ability to move towards the minus-end of the microtubules, known as retrograde transport; thus, they are called "minus-end directed motors". In contrast, most kinesin motor proteins move toward the microtubules' plus-end, in what is called anterograde transport.
==Classification==
Excerpted from Wikipedia’s “dynein” article, available under the CC BY-SA 4.0 licence.