dynactin complex
Sign in to saveAlso known as GO:0005869, Dynactin
thumb|400px|Quaternary structure of dynactin Dynactin is a 23 subunit protein complex that acts as a co-factor for the microtubule motor cytoplasmic dynein-1. It is built around a short filament of actin related protein-1 (Arp1).
Research
1,192 papers- Molecular mechanism of dynein-dynactin complex assembly by LIS1.Science (New York, N.Y.) · 2024
- The role of the dynactin complex in intracellular motility.International review of cytology · 1998
- Dynactin.Annual review of cell and developmental biology · 2004
- Role of dynein-dynactin complex, kinesins, motor adaptors, and their phosphorylation in dendritogenesis.Journal of neurochemistry · 2020
- Ndel1 disfavors dynein-dynactin-adaptor complex formation in two distinct ways.The Journal of biological chemistry · 2023
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Article
7 sectionsContents
- Discovery
- Structure
- Interaction with dynein
- Functions
- See also
- References
- Further reading
thumb|400px|Quaternary structure of dynactin Dynactin is a 23 subunit protein complex that acts as a co-factor for the microtubule motor cytoplasmic dynein-1. It is built around a short filament of actin related protein-1 (Arp1).
==Discovery== Dynactin was identified as an activity that allowed purified cytoplasmic dynein to move membrane vesicles along microtubules in vitro. It was shown to be a multiprotein complex and named "dynactin" because of its role in dynein activation.