CDC42
Sign in to saveAlso known as CDC42Hs, G25K, TKS, cell division cycle 42
Cell division control protein 42 homolog (Cdc42 or CDC42) is a protein that in humans is encoded by the CDC42 gene. Cdc42 is involved in regulation of the cell cycle. It was originally identified in S. cerevisiae (yeast) as a mediator of cell division, and is now known to influence a variety of signaling events and cellular processes in a variety of organisms from yeast to mammals.
Gene data
CDC42- Name
- cell division cycle 42
- Type
- protein-coding
- Position
- 22,052,627–22,101,360 (+)
- Aliases
- CDC42Hs, G25K, TKS
- Ensembl
- ENSG00000070831
- RefSeq RNA
- NM_001039802.2, NM_001791.4, NM_044472.3
- RefSeq protein
- NP_001034891.1, NP_001782.1, NP_426359.1
The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
cell division cycle 42
- Symbol
- CDC42
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:22,052,627-22,101,360
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- CDC42.png
Show 6 more facts
- HomoloGene ID
- 123986
- exact match
- identifiers.org/ncbigene/998
- genomic end
- 22101360
- genomic start
- 22052627
- cytogenetic location
- 1p36.12
- Commons category
- CDC42
Sources (8)
via Wikidata · CC0
~6 min read
Article
8 sectionsContents
- Function
- Structure
- Role in cancer
- Takenouchi-Kosaki syndrome
- Interactions
- See also
- References
- External links
Cell division control protein 42 homolog (Cdc42 or CDC42) is a protein that in humans is encoded by the CDC42 gene. Cdc42 is involved in regulation of the cell cycle. It was originally identified in S. cerevisiae (yeast) as a mediator of cell division, and is now known to influence a variety of signaling events and cellular processes in a variety of organisms from yeast to mammals.
== Function == Human Cdc42 is a small GTPase of the Rho family, which regulates signaling pathways that control diverse cellular functions including cell morphology, cell migration, endocytosis, cell polarity and cell cycle progression. Rho GTPases are central to dynamic actin cytoskeletal assembly and rearrangement that are the basis of cell-cell adhesion and migration. Activated Cdc42 activates by causing conformational changes in p21-activated kinases PAK1 and PAK2, which in turn initiate actin reorganization and regulate cell adhesion, migration, and invasion.