CDK6

Also known as MCPH12, PLSTIRE, cyclin-dependent kinase 6, cyclin dependent kinase 6

protein-coding gene in the species Homo sapiens

Gene data

CDK6

Name: cyclin dependent kinase 6
Type: protein-coding
Position: 92,604,921–92,836,591 (−)
Aliases: MCPH12, PLSTIRE
Ensembl: ENSG00000105810
RefSeq RNA: NM_001145306.2, NM_001259.8, XM_047419716.1
RefSeq protein: NP_001138778.1, NP_001250.1, XP_047275672.1

The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017].