CDKN2D

Also known as INK4D, p19, p19-INK4D, cyclin-dependent kinase inhibitor 2D, cyclin dependent kinase inhibitor 2D

Cyclin-dependent kinase 4 inhibitor D is an enzyme that in humans is encoded by the CDKN2D gene.

Gene data

CDKN2D

Name: cyclin dependent kinase inhibitor 2D
Type: protein-coding
Position: 10,566,460–10,569,059 (−)
Aliases: INK4D, p19, p19-INK4D
Ensembl: ENSG00000129355
RefSeq RNA: NM_001800.4, NM_079421.3
RefSeq protein: NP_001791.1, NP_524145.1

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008].

Pathways

FoxO signaling pathway - Homo sapiens (human)Cell cycle - Homo sapiens (human)Cell Cycle Cellular responses to stress Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP)Cellular Senescence Oncogene Induced Senescence Mitotic G1 phase and G1/S transition Cyclin D associated events in G1

via MyGene.info

Gene · Ensembl

cyclin dependent kinase inhibitor 2D

Symbol: CDKN2D
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:10,566,460-10,569,059
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein CDKN2D PDB 1bd8.png

Show 5 more facts

HomoloGene ID: 36081
exact match: identifiers.org/ncbigene/1032
genomic start: 10566460
genomic end: 10679735
cytogenetic location: 19p13.2

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Cyclin-dependent kinase 4 inhibitor D is an enzyme that in humans is encoded by the CDKN2D gene.

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. The expression of this gene and its protein product (p19) is observed in neurons with neurofibrillary tangles (NFTs) and it is suggested as a marker for senescent neurons. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.