CDK4

Name

cyclin dependent kinase 4

Type

protein-coding

Position

57,747,722–57,756,013 (−)

Aliases

CMM3, MCPH31, PSK-J3

Ensembl

ENSG00000135446

RefSeq RNA

NM_000075.4, NM_052984.1

RefSeq protein

NP_000066.1

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

cyclin dependent kinase 4

Symbol

CDK4

Biotype

Protein coding

Organism

Homo sapiens

Location

12:57,746,043-57,756,013

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

Protein CDK4 PDB 1LD2.png

via Wikidata · CC0