CDC25A
Sign in to saveAlso known as CDC25A2, cell division cycle 25A
M-phase inducer phosphatase 1 also known as dual specificity phosphatase Cdc25A is a protein that in humans is encoded by the cell division cycle 25 homolog A (CDC25A) gene.
Gene data
CDC25A- Name
- cell division cycle 25A
- Type
- protein-coding
- Position
- 48,157,146–48,188,417 (−)
- Aliases
- CDC25A2
- Ensembl
- ENSG00000164045
- RefSeq RNA
- NM_001789.3, NM_201567.2, XM_047449363.1, XM_047449364.1, XM_047449365.1
- RefSeq protein
- NP_001780.2, NP_963861.1, XP_047305319.1, XP_047305320.1, XP_047305321.1
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
cell division cycle 25A
- Symbol
- CDC25A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:48,157,146-48,188,428
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein CDC25A PDB 1c25.png
Show 5 more facts
- HomoloGene ID
- 1355
- exact match
- identifiers.org/ncbigene/993
- genomic end
- 48188417
- genomic start
- 48198636
- cytogenetic location
- 3p21.31
via Wikidata · CC0
~2 min read
Article
6 sectionsContents
- Function
- Involvement in cancer
- Interactions
- References
- External links
- Further reading
M-phase inducer phosphatase 1 also known as dual specificity phosphatase Cdc25A is a protein that in humans is encoded by the cell division cycle 25 homolog A (CDC25A) gene.
== Function ==