Gene data
CDC25A- Name
- cell division cycle 25A
- Type
- protein-coding
- Position
- 48,157,146–48,188,428 (−)
- Aliases
- CDC25A2
- Ensembl
- ENSG00000164045
- RefSeq RNA
- NM_001789.3, NM_201567.2, XM_047449363.1, XM_047449364.1, XM_047449365.1
- RefSeq protein
- NP_001780.2, NP_963861.1, XP_047305319.1, XP_047305320.1, XP_047305321.1
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
regulation of cyclin-dependent protein serine/threonine kinase activityG1/S transition of mitotic cell cycleG2/M transition of mitotic cell cycleG2/M transition of mitotic cell cycleG2/M transition of mitotic cell cycleG2/M transition of mitotic cell cyclecell population proliferationcell population proliferation
Molecular function
Pathways
Cell cycle - Homo sapiens (human)Cellular senescence - Homo sapiens (human)Progesterone-mediated oocyte maturation - Homo sapiens (human)MicroRNAs in cancer - Homo sapiens (human)Transcription of E2F targets under negative control by DREAM complexG0 and Early G1Polo-like kinase mediated eventsCell CycleDiseaseActivation of ATR in response to replication stress
via MyGene.info
Gene · Ensembl
cell division cycle 25A
- Symbol
- CDC25A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:48,157,146-48,188,428
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein CDC25A PDB 1c25.png
Show 8 more facts
- HomoloGene ID
- 1355
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/993
- genomic end
- 48188417
- genomic start
- 48198636
- chromosome
- human chromosome 3
- cytogenetic location
- 3p21.31
- expressed in
- bone marrow
via Wikidata · CC0