PTPN7

Name

protein tyrosine phosphatase non-receptor type 7

Type

protein-coding

Position

202,147,012–202,161,588 (−)

Aliases

BPTP-4, HEPTP, LC-PTP, LPTP, PTPNI

Ensembl

ENSG00000143851

RefSeq RNA

NM_001199797.2, NM_001364877.2, NM_001364878.1, NM_002832.4, NM_080588.3

RefSeq protein

NP_001186726.1, NP_001351806.1, NP_001351807.1, NP_002823.4, NP_542155.1

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010].

via MyGene.info

Gene · Ensembl

protein tyrosine phosphatase non-receptor type 7

Symbol

PTPN7

Biotype

Protein coding

Organism

Homo sapiens

Location

1:202,147,012-202,161,588

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein PTPN7 PDB 1zc0.png

via Wikidata · CC0