DUSP3
Sign in to saveAlso known as VHR, dual specificity phosphatase 3
Dual specificity protein phosphatase 3 is an enzyme that in humans is encoded by the DUSP3 gene.
Gene data
DUSP3- Name
- dual specificity phosphatase 3
- Type
- protein-coding
- Aliases
- VHR
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
dual specificity phosphatase 3
- Symbol
- DUSP3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:43,763,629-43,779,000
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein DUSP3 PDB 1j4x.png
Show 5 more facts
- HomoloGene ID
- 20870
- exact match
- identifiers.org/ncbigene/1845
- genomic end
- 43778977
- genomic start
- 43766125
- cytogenetic location
- 17q21.31
Sources (3)
via Wikidata · CC0
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Article
3 sectionsContents
- Interactions
- References
- Further reading
Dual specificity protein phosphatase 3 is an enzyme that in humans is encoded by the DUSP3 gene.
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.