DUSP5

Also known as DUSP, HVH3, dual specificity phosphatase 5

Dual specificity protein phosphatase 5 is an enzyme that in humans is encoded by the DUSP5 gene.

Gene data

DUSP5

Name: dual specificity phosphatase 5
Type: protein-coding
Aliases: DUSP, HVH3

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008].

via MyGene.info