PTPRO

Also known as GLEPP1, NPHS6, PTP-OC, PTP-U2, PTPROT, PTPU2, R-PTP-O, protein tyrosine phosphatase, receptor type O

Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the PTPRO gene.

Gene data

PTPRO

Name: protein tyrosine phosphatase receptor type O
Type: protein-coding
Aliases: GLEPP1, NPHS6, PTP-OC, PTP-U2, PTPROT, PTPU2, R-PTP-O

This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011].

via MyGene.info

Gene · Ensembl

protein tyrosine phosphatase receptor type O

Symbol: PTPRO
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:15,322,257-15,602,175
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein PTPRO PDB 2g59.png

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HomoloGene ID: 21564
exact match: identifiers.org/ncbigene/5800
genomic end: 15602175
genomic start: 15322257
cytogenetic location: 12p12.3|12p13-p12

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Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the PTPRO gene.

This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic signature motif. The gene product, which has a transmembrane domain, is an integral membrane protein. Several alternatively spliced transcript variants, some of which encode different isoforms of the protein, have been described. These variants exhibit tissue-specific expression.