PSTPIP2

Also known as MAYP, proline-serine-threonine phosphatase interacting protein 2

Proline-serine-threonine phosphatase-interacting protein 2 is an enzyme that in humans is encoded by the PSTPIP2 gene. This protein, also known as macrophage F-actin-associated and tyrosine phosphorylated protein (MAYP) is a member of the Pombe Cdc15 homology (PCH) family of proteins has been shown to coordinate membrane and cytoskeletal dynamics

Gene data

PSTPIP2

Name: proline-serine-threonine phosphatase interacting protein 2
Type: protein-coding
Position: 45,983,536–46,072,296 (−)
Aliases: MAYP
Ensembl: ENSG00000152229
RefSeq RNA: NM_024430.4
RefSeq protein: NP_077748.3

Predicted to enable actin filament binding activity. Predicted to be involved in actin filament polymerization. Predicted to be located in cytoskeleton and membrane. Predicted to be active in actin filament; cytoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Cellular component

cytoplasm cytoplasm cytosol cytoskeleton plasma membrane membrane

via MyGene.info

Gene · Ensembl

proline-serine-threonine phosphatase interacting protein 2

Symbol: PSTPIP2
Biotype: Protein coding
Organism: Homo sapiens
Location: 18:45,983,536-46,072,367
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 69150
exact match: identifiers.org/ncbigene/9050
genomic end: 43652238
genomic start: 43563502
cytogenetic location: 18q21.1|tdb7990

Sources (3)

via Wikidata · CC0

~2 min read

Article

6 sections

Contents

Function
Cytokine expression profile
Disease linkage
Interactions
References
Further reading

== Function == Pstpip2 is selectively expressed in macrophages and macrophage precursors, and it is an actin bundling protein which regulates filopodia formation and macrophage motility