PTPA
Sign in to saveAlso known as PP2A, PR53, PPP2R4, protein phosphatase 2 regulatory subunit 4, protein phosphatase 2 phosphatase activator
Serine/threonine-protein phosphatase 2A regulatory subunit B is an enzyme that in humans is encoded by the PPP2R4 gene.
In the Vinony graph
Within Vinony's link graph, PTPA is referenced by 5 other articles, and connects out to PubMed, human chromosome 9 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 9.
Its subject is documented across 4 Wikipedia language editions.
Gene data
PTPA- Name
- protein phosphatase 2 phosphatase activator
- Type
- protein-coding
- Position
- 129,110,550–129,148,946 (+)
- Aliases
- PARK25, PP2A, PPP2R4, PR53
- Ensembl
- ENSG00000119383
- RefSeq RNA
- NM_001193397.2, NM_001271832.2, NM_021131.5, NM_178000.3, NM_178001.3
- RefSeq protein
- NP_001180326.1, NP_001258761.1, NP_066954.2, NP_821067.1, NP_821068.1
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
protein phosphatase 2 phosphatase activator
- Symbol
- PTPA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:129,110,550-129,148,946
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein PPP2R4 PDB 2g62.png
Show 9 more facts
- HomoloGene ID
- 6149
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5524
- genomic end
- 131911225
- genomic start
- 131873229
- chromosome
- human chromosome 9
- cytogenetic location
- 9q34.11
- expressed in
- amygdala
- Commons category
- PPP2R4
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Serine/threonine-protein phosphatase 2A regulatory subunit B is an enzyme that in humans is encoded by the PPP2R4 gene.
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.
Excerpted from Wikipedia’s “PTPA” article, available under the CC BY-SA 4.0 licence.