PPP2R1A

Also known as PP2A-Aalpha, PP2AAALPHA, PR65A, MRD36, protein phosphatase 2 scaffold subunit Aalpha, PP2AA

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is an enzyme that in humans is encoded by the PPP2R1A gene. In the plant Arabidopsis thaliana a similar enzyme is encoded by the RCN1 gene (At1g25490).

Gene data

PPP2R1A

Name: protein phosphatase 2 scaffold subunit Aalpha
Type: protein-coding
Position: 52,170,936–52,229,518 (+)
Aliases: HJS2, MRD36, PP2A-Aalpha, PP2AA, PP2AAALPHA, PR65A
Ensembl: ENSG00000105568
RefSeq RNA: NM_001363656.2, NM_014225.6, NR_033500.2
RefSeq protein: NP_001350585.1, NP_055040.2

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010].

Gene Ontology

Biological process

~1 min read

Article

6 sections

Contents

Function
Role in human pathology
Interactions
Arabidopsis RCN1
References
Further reading

== Function == This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A.