PPM1A
Sign in to saveAlso known as PP2C-ALPHA, PP2CA, PP2Calpha, protein phosphatase, Mg2+/Mn2+ dependent 1A
Protein phosphatase 1A is an enzyme that in humans is encoded by the PPM1A gene.
Gene data
PPM1A- Name
- protein phosphatase, Mg2+/Mn2+ dependent 1A
- Type
- protein-coding
- Aliases
- PP2C-ALPHA, PP2CA, PP2Calpha
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
protein phosphatase, Mg2+/Mn2+ dependent 1A
- Symbol
- PPM1A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:60,245,752-60,299,223
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein PPM1A PDB 1a6q.png
Show 5 more facts
- HomoloGene ID
- 56428
- exact match
- identifiers.org/ncbigene/5494
- genomic end
- 60765805
- genomic start
- 60712470
- cytogenetic location
- 14q23.1
Sources (4)
via Wikidata · CC0
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- Further reading
Protein phosphatase 1A is an enzyme that in humans is encoded by the PPM1A gene.
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding two distinct isoforms have been described.