PPM1B
Sign in to saveAlso known as PP2C-beta, PP2C-beta-X, PP2CB, PP2CBETA, PPC2BETAX, protein phosphatase, Mg2+/Mn2+ dependent 1B
Protein phosphatase 1B is an enzyme that in humans is encoded by the PPM1B gene.
Gene data
PPM1B- Name
- protein phosphatase, Mg2+/Mn2+ dependent 1B
- Type
- protein-coding
- Aliases
- PP2C-beta, PP2C-beta-X, PP2CB, PP2CBETA, PPC2BETAX
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
protein phosphatase, Mg2+/Mn2+ dependent 1B
- Symbol
- PPM1B
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:44,167,969-44,244,384
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein PPM1B PDB 2p8e.png
Show 5 more facts
- HomoloGene ID
- 2027
- exact match
- identifiers.org/ncbigene/5495
- genomic end
- 44471523
- genomic start
- 44395108
- cytogenetic location
- 2p21
Sources (3)
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Function
- Interactions
- References
- Further reading
Protein phosphatase 1B is an enzyme that in humans is encoded by the PPM1B gene.
== Function ==