PPP1R1B

Also known as DARPP-32, DARPP32, protein phosphatase 1 regulatory inhibitor subunit 1B

Protein phosphatase 1 regulatory subunit 1B (PPP1R1B), also known as dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32), is a protein that in humans is encoded by the PPP1R1B gene.

Gene data

PPP1R1B

Name: protein phosphatase 1 regulatory inhibitor subunit 1B
Type: protein-coding
Position: 39,626,740–39,636,626 (+)
Aliases: DARPP-32, DARPP32
Ensembl: ENSG00000131771
RefSeq RNA: NM_001242464.2, NM_032192.4, NM_181505.4, XM_017025216.3, XM_017025217.3
RefSeq protein: NP_001229393.1, NP_115568.2, NP_852606.1, XP_016880705.1, XP_016880706.1

This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

Gene Ontology

Biological process

signal transduction signal transduction

~4 min read

Article

9 sections

Contents

Function
Clinical significance
CNS
Cancer
Regulation
Discovery
Interactive pathway map
References
Further reading

Protein phosphatase 1 regulatory subunit 1B (PPP1R1B), also known as dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32), is a protein that in humans is encoded by the PPP1R1B gene.

== Function ==