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GeneQ18047432· pop 7· linked from 35 articles

PPP1R1B

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Also known as DARPP-32, DARPP32, protein phosphatase 1 regulatory inhibitor subunit 1B

Protein phosphatase 1 regulatory subunit 1B (PPP1R1B), also known as dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32), is a protein that in humans is encoded by the PPP1R1B gene.

Gene data

PPP1R1B
Name
protein phosphatase 1 regulatory inhibitor subunit 1B
Type
protein-coding
Position
39,626,740–39,636,626 (+)
Aliases
DARPP-32, DARPP32
Ensembl
ENSG00000131771
RefSeq RNA
NM_001242464.2, NM_032192.4, NM_181505.4, XM_017025216.3, XM_017025217.3
RefSeq protein
NP_001229393.1, NP_115568.2, NP_852606.1, XP_016880705.1, XP_016880706.1

This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

Gene Ontology

Pathways

cAMP signaling pathway - Homo sapiens (human)Dopaminergic synapse - Homo sapiens (human)Cocaine addiction - Homo sapiens (human)Amphetamine addiction - Homo sapiens (human)Alcoholism - Homo sapiens (human)Opioid SignallingOpioid SignallingSignal TransductionSignal TransductionDARPP-32 events

via MyGene.info

Gene · Ensembl

protein phosphatase 1 regulatory inhibitor subunit 1B

Symbol
PPP1R1B
Biotype
Protein coding
Organism
Homo sapiens
Location
17:39,626,740-39,636,626
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of
gene
Show 8 more facts
HomoloGene ID
12972
found in taxon
Homo sapiens
exact match
identifiers.org/ncbigene/84152
genomic end
37792879
genomic start
37782993
chromosome
human chromosome 17
cytogenetic location
17q12
expressed in
Brodmann area 9
Sources (4)

via Wikidata · CC0

~4 min read

Encyclopedic overview

9 sections
Contents
  • Function
  • Clinical significance
  • CNS
  • Cancer
  • Regulation
  • Discovery
  • Interactive pathway map
  • References
  • Further reading

Protein phosphatase 1 regulatory subunit 1B (PPP1R1B), also known as dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32), is a protein that in humans is encoded by the PPP1R1B gene.

== Function ==

Excerpted from Wikipedia’s “PPP1R1B” article, available under the CC BY-SA 4.0 licence.

Available in 7 languages

via Wikidata sitelinks · CC0