ADCY2
Sign in to saveAlso known as AC2, HBAC2, adenylate cyclase 2 (brain), adenylate cyclase 2
Adenylyl cyclase type 2 is an enzyme typically expressed in the brain of humans, that is encoded by the ADCY2 gene. It belongs to the adenylyl cyclase class-3 or guanylyl cyclase family because it contains two guanylate cyclase domains. ADCY2 is one of ten different mammalian isoforms of adenylyl cyclases. ADCY2 can be found on chromosome 5 and the "MIR2113-POU3F2" region of chromosome 6, with a length of 1091 amino-acids. An essential cofactor for ADCY2 is magnesium; two ions bind per subunit.
In the Vinony graph
Within Vinony's link graph, ADCY2 is referenced by 50 other articles, and connects out to Q180686, adenosine cyclic phosphate and Ensembl genome database project.
Vinony files it under EC 4.6.1 and Genes on human chromosome 5.
Its subject is documented across 4 Wikipedia language editions.
Gene data
ADCY2- Name
- adenylate cyclase 2
- Type
- protein-coding
- Position
- 7,395,681–7,830,638 (+)
- Aliases
- AC2, HBAC2
- Ensembl
- ENSG00000078295
- RefSeq RNA
- NM_020546.3, XM_011513942.3, XM_047416645.1, XM_047416646.1, XM_047416647.1
- RefSeq protein
- NP_065433.2, XP_011512244.1, XP_047272601.1, XP_047272602.1, XP_047272603.1
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
adenylate cyclase 2
- Symbol
- ADCY2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:7,395,681-7,830,638
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein ADCY2 PDB 1ab8.png
Show 5 more facts
- HomoloGene ID
- 75133
- exact match
- identifiers.org/ncbigene/108
- genomic end
- 7830194
- genomic start
- 7396138
- cytogenetic location
- 5p15.31
via Wikidata · CC0
~3 min read
Encyclopedic overview
7 sectionsContents
- Structure
- Function
- Clinical significance
- Interactive pathway map
- References
- External links
- Further reading
Adenylyl cyclase type 2 is an enzyme typically expressed in the brain of humans, that is encoded by the ADCY2 gene. It belongs to the adenylyl cyclase class-3 or guanylyl cyclase family because it contains two guanylate cyclase domains. ADCY2 is one of ten different mammalian isoforms of adenylyl cyclases. ADCY2 can be found on chromosome 5 and the "MIR2113-POU3F2" region of chromosome 6, with a length of 1091 amino-acids. An essential cofactor for ADCY2 is magnesium; two ions bind per subunit.
== Structure ==
Excerpted from Wikipedia’s “ADCY2” article, available under the CC BY-SA 4.0 licence.