STX1A
Sign in to saveAlso known as HPC-1, P35-1, STX1, SYN1A, syntaxin 1A
Syntaxin-1A is a protein that in humans is encoded by the STX1A gene.
Gene data
STX1A- Name
- syntaxin 1A
- Type
- protein-coding
- Position
- 73,699,205–73,719,706 (−)
- Aliases
- HPC-1, P35-1, STX1, SYN1A
- Ensembl
- ENSG00000106089
- RefSeq RNA
- NM_001165903.2, NM_004603.4, XM_047420777.1, XM_047420778.1, XM_054358896.1
- RefSeq protein
- NP_001159375.1, NP_004594.1, XP_047276733.1, XP_047276734.1, XP_054214871.1
This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
syntaxin 1A
- Symbol
- STX1A
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:73,699,205-73,719,706
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Three-dimensional structure of the complexin SNARE complex - Syntaxin-1A 1KIL.png
Show 8 more facts
- HomoloGene ID
- 37941
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6804
- chromosome
- human chromosome 7
- genomic start
- 73113536
- genomic end
- 73134002
- cytogenetic location
- 7q11.23
- expressed in
- islet of Langerhans
via Wikidata · CC0
~2 min read
Encyclopedic overview
8 sectionsContents
- Function
- Clinical significance
- Interactive pathway map
- Interactions
- See also
- References
- Further reading
- External links
Syntaxin-1A is a protein that in humans is encoded by the STX1A gene.
== Function == Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process.
Excerpted from Wikipedia’s “STX1A” article, available under the CC BY-SA 4.0 licence.