CPSF1

Also known as CPSF160, HSU37012, P/cl.18, cleavage and polyadenylation specific factor 1

Cleavage and polyadenylation specificity factor subunit 1 is a protein that in humans is encoded by the CPSF1 gene.

In the Vinony graph

Vinony's link graph records 7 inbound references to CPSF1, and connects out to PubMed, human chromosome 8 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 8.

Vinony links it to 5 Wikipedia language editions.

Gene data

CPSF1

Name: cleavage and polyadenylation specific factor 1
Type: protein-coding
Position: 144,393,229–144,409,864 (−)
Aliases: CPSF160, HSU37012, MYP27, P/cl.18
Ensembl: ENSG00000285049
RefSeq RNA: NM_013291.3, XM_006716548.3, XM_047421732.1, XM_047421733.1, XM_047421734.1
RefSeq protein: NP_037423.2, XP_006716611.1, XP_047277688.1, XP_047277689.1, XP_047277690.1

Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008].

Gene Ontology

Biological process

mRNA 3'-end processing mRNA 3'-end processing co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway

Molecular function

nucleic acid binding protein binding enzyme binding mRNA 3'-UTR AU-rich region binding

Cellular component

nucleus nucleus nucleoplasm nucleoplasm nucleoplasm mRNA cleavage and polyadenylation specificity factor complex mRNA cleavage and polyadenylation specificity factor complex

Pathways

mRNA surveillance pathway - Homo sapiens (human)Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNAs Derived from Intronless Transcripts Disease Infectious disease tRNA processing in the nucleus mRNA 3'-end processing Transport of Mature Transcript to Cytoplasm Processing of Capped Intron-Containing Pre-mRNA tRNA processing

via MyGene.info

Gene · Ensembl

cleavage and polyadenylation specific factor 1

Symbol: CPSF1
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:144,393,229-144,409,864
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: CRYO-EM STRUCTURE OF the human MPSF - Cleavage and polyadenylation specificity factor subunit 1 8E3Q.png

Show 8 more facts

HomoloGene ID: 40865
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/29894
chromosome: human chromosome 8
genomic start: 145618444
genomic end: 145634753
cytogenetic location: 8q24.3
expressed in: spleen

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

3 sections

Contents

References
Further reading
External links

Cleavage and polyadenylation specificity factor subunit 1 is a protein that in humans is encoded by the CPSF1 gene.

In most cases eukaryotic pre-messenger(m)RNA 3 prime ends are processed in two coordinated steps. First there is a site-specific cleavage by an endonuclease and then the addition of a poly(A) tail at the 3 prime end of the 5 prime cleavage product. Cleavage requires four multisubunit complexes, namely cleavage and polyadenylation specificity factor (CPSF), cleavage stimulation factor (CstF), cleavage factors Im and IIm (CFIm and CFIIm), along with a single subunit poly(A)polymerase (PAP). CPSF1 is the largest component of the CPSF complex composed of CPSF1, CPSF2, CPSF3, CPSF4, FIP1L1, Symplekin and WDR33 and located in the nucleus.

Excerpted from Wikipedia’s “CPSF1” article, available under the CC BY-SA 4.0 licence.