CPSF1

Also known as CPSF160, HSU37012, P/cl.18, cleavage and polyadenylation specific factor 1

Cleavage and polyadenylation specificity factor subunit 1 is a protein that in humans is encoded by the CPSF1 gene.

Gene data

CPSF1

Name: cleavage and polyadenylation specific factor 1
Type: protein-coding
Aliases: CPSF160, HSU37012, MYP27, P/cl.18

Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008].

via MyGene.info

Gene · Ensembl

cleavage and polyadenylation specific factor 1

Symbol: CPSF1
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:144,393,229-144,409,864
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Image: CRYO-EM STRUCTURE OF the human MPSF - Cleavage and polyadenylation specificity factor subunit 1 8E3Q.png

Show 5 more facts

HomoloGene ID: 40865
exact match: identifiers.org/ncbigene/29894
genomic start: 145618444
genomic end: 145634753
cytogenetic location: 8q24.3

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Cleavage and polyadenylation specificity factor subunit 1 is a protein that in humans is encoded by the CPSF1 gene.

In most cases eukaryotic pre-messenger(m)RNA 3 prime ends are processed in two coordinated steps. First there is a site-specific cleavage by an endonuclease and then the addition of a poly(A) tail at the 3 prime end of the 5 prime cleavage product. Cleavage requires four multisubunit complexes, namely cleavage and polyadenylation specificity factor (CPSF), cleavage stimulation factor (CstF), cleavage factors Im and IIm (CFIm and CFIIm), along with a single subunit poly(A)polymerase (PAP). CPSF1 is the largest component of the CPSF complex composed of CPSF1, CPSF2, CPSF3, CPSF4, FIP1L1, Symplekin and WDR33 and located in the nucleus.