PAPOLA

Also known as PAP, poly(A) polymerase alpha, PAP-alpha

Poly(A) polymerase alpha is an enzyme that in humans is encoded by the PAPOLA gene.

Gene data

PAPOLA

Name: poly(A) polymerase alpha
Type: protein-coding
Position: 96,501,433–96,567,118 (+)
Aliases: PAP, PAP-alpha
Ensembl: ENSG00000090060
RefSeq RNA: NM_001252006.1, NM_001252007.1, NM_001293627.1, NM_001293628.2, NM_001293632.3
RefSeq protein: NP_001238935.1, NP_001238936.1, NP_001280556.1, NP_001280557.1, NP_001280561.1

The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

Pathways

mRNA surveillance pathway - Homo sapiens (human)Disease Infectious disease mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination RNA Polymerase II Transcription Gene expression (Transcription)Processing of Capped Intronless Pre-mRNA Processing of Intronless Pre-mRNAs

via MyGene.info

Gene · Ensembl

poly(A) polymerase alpha

Symbol: PAPOLA
Biotype: Protein coding
Organism: Homo sapiens
Location: 14:96,501,433-96,567,118
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

2 sections

Contents

References
Further reading

Poly(A) polymerase alpha is an enzyme that in humans is encoded by the PAPOLA gene.

PAPOLA binds to FIP1L1 (Factor interacting with PAPOLA and CPSF1), a subunit of the cleavage and polyadenylation specificity factor subunit 1 (CPSF1) complex. This complex polyadenylates the 3' end of precursor mRNAs (pre-mRNA) (see CPSF). CPSF1 is an RNA processing protein that binds to uracil-rich sequences in pre-mRNA, binds with and stimulates PAPOLA's Polynucleotide adenylyltransferase activity, and thereby adds adenylyl residues to pre-mRNA. This poly-adenylyl action increases pre mRNA's maturation and movement from the nucleus to cytoplasm while dramatically increasing the stability of the mRNA formed from pre-mRNA: FIP1L1 is a Pre-mRNA 3'-end-processing factor. FIP1L1 gene fusions between it and either the platelet-derived growth factor receptor, alpha (PGDFRA) or Retinoic acid receptor alpha (RARA) genes are causes of certain human diseases associated with pathologically increased levels of blood eosinophils and/or Leukemias.

Excerpted from Wikipedia’s “PAPOLA” article, available under the CC BY-SA 4.0 licence.