CPSF2
Sign in to saveAlso known as CPSF100, cleavage and polyadenylation specific factor 2
Cleavage and polyadenylation specificity factor subunit 2 is a protein that in humans is encoded by the CPSF2 gene. This protein is a subunit of the cleavage and polyadenylation specificity factor (CPSF) complex which plays a key role in pre-mRNA 3' end processing and polyadenylation. The CPSF2 protein connects the two subunits of the complex, mCF and mPSF. Its structure contributes both to the stability of the subunits interaction and to the flexibility of the complex necessary for function. This protein has been identified as an essential subunit of the complex as certain mutations in the re
Gene data
CPSF2- Name
- cleavage and polyadenylation specific factor 2
- Type
- protein-coding
- Aliases
- CPSF100
Predicted to enable RNA binding activity. Involved in mRNA 3'-end processing by stem-loop binding activity and cleavage. Located in membrane. Part of mRNA cleavage and polyadenylation specificity factor complex. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Gene · Ensembl
cleavage and polyadenylation specific factor 2
- Symbol
- CPSF2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:92,121,512-92,172,145
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Cryo-EM structure of human CPSF160-WDR33-CPSF30-CPSF100 PIM complex - Cleavage and polyadenylation specificity factor subunit 2 (2) 6URG.png
Show 5 more facts
- HomoloGene ID
- 6460
- exact match
- identifiers.org/ncbigene/53981
- genomic end
- 92630755
- genomic start
- 92121969
- cytogenetic location
- 14q32.12
Sources (4)
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- References
- External links
- Further reading
Cleavage and polyadenylation specificity factor subunit 2 is a protein that in humans is encoded by the CPSF2 gene. This protein is a subunit of the cleavage and polyadenylation specificity factor (CPSF) complex which plays a key role in pre-mRNA 3' end processing and polyadenylation. The CPSF2 protein connects the two subunits of the complex, mCF and mPSF. Its structure contributes both to the stability of the subunits interaction and to the flexibility of the complex necessary for function. This protein has been identified as an essential subunit of the complex as certain mutations in the region inhibit CPSF complex formation.
==References==