BPTF

Also known as FAC1, FALZ, NURF301, bromodomain PHD finger transcription factor, NEDDFL

Nucleosome-remodeling factor subunit BPTF is a protein that in humans is encoded by the BPTF gene.

In the Vinony graph

Vinony's link graph records 4 inbound references to BPTF, and connects out to PubMed, human chromosome 17 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 17.

Vinony links it to 6 Wikipedia language editions.

Gene data

BPTF

Name: bromodomain PHD finger transcription factor
Type: protein-coding
Position: 67,825,488–67,984,378 (+)
Aliases: FAC1, FALZ, NEDDFL, NURF301
Ensembl: ENSG00000171634
RefSeq RNA: NM_001439139.1, NM_001439140.1, NM_001439141.1, NM_001439142.1, NM_001439143.1
RefSeq protein: NP_001426068.1, NP_001426069.1, NP_001426070.1, NP_001426071.1, NP_001426072.1

This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008].