BPTF
Sign in to saveAlso known as FAC1, FALZ, NURF301, bromodomain PHD finger transcription factor, NEDDFL
Nucleosome-remodeling factor subunit BPTF is a protein that in humans is encoded by the BPTF gene.
Gene data
BPTF- Name
- bromodomain PHD finger transcription factor
- Type
- protein-coding
- Position
- 67,825,503–67,984,378 (+)
- Aliases
- FAC1, FALZ, NEDDFL, NURF301
- Ensembl
- ENSG00000171634
- RefSeq RNA
- NM_001439139.1, NM_001439140.1, NM_001439141.1, NM_001439142.1, NM_001439143.1
- RefSeq protein
- NP_001426068.1, NP_001426069.1, NP_001426070.1, NP_001426071.1, NP_001426072.1
This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
bromodomain PHD finger transcription factor
- Symbol
- BPTF
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:67,825,488-67,984,378
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein BPTF PDB 2f6j.png
Show 5 more facts
- HomoloGene ID
- 114397
- exact match
- identifiers.org/ncbigene/2186
- genomic start
- 67825503
- genomic end
- 65980494
- cytogenetic location
- 17q24.2
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Interactions
- References
- External links
- Further reading
Nucleosome-remodeling factor subunit BPTF is a protein that in humans is encoded by the BPTF gene.
This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely.