CBFB

Also known as PEBP2B, core-binding factor, beta subunit, core-binding factor beta subunit, core-binding factor subunit beta

Core-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene.

Gene data

CBFB

Name: core-binding factor subunit beta
Type: protein-coding
Position: 67,028,984–67,101,058 (+)
Aliases: CLCD2, PEBP2B
Ensembl: ENSG00000067955
RefSeq RNA: NM_001368707.1, NM_001368708.1, NM_001368709.1, NM_001368710.1, NM_001755.3
RefSeq protein: NP_001355636.1, NP_001355637.1, NP_001355638.1, NP_001355639.1, NP_001746.1

The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Pathways

Developmental Biology Signal Transduction Generic Transcription Pathway Generic Transcription Pathway RNA Polymerase II Transcription RNA Polymerase II Transcription Gene expression (Transcription)Gene expression (Transcription)RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)Transcriptional regulation by RUNX3

via MyGene.info

Gene · Ensembl

core-binding factor subunit beta

Symbol: CBFB
Biotype: Protein coding
Organism: Homo sapiens
Location: 16:67,028,984-67,101,058
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein CBFB PDB 1cl3.png

Show 5 more facts

HomoloGene ID: 11173
exact match: identifiers.org/ncbigene/865
genomic end: 67134961
genomic start: 67028984
cytogenetic location: 16q22.1

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Core-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene.

The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by the alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene.