MRTFA
Sign in to saveAlso known as BSAC, MAL, MRTF-A, megakaryoblastic leukemia (translocation) 1, MKL, MKL1, myocardin related transcription factor A
MKL/megakaryoblastic leukemia 1 (also termed MRTFA/myocardin related transcription factor A) is a protein that in humans is encoded by the MKL1 gene.
In the Vinony graph
Within Vinony's link graph, MRTFA is referenced by 111 other articles, and connects out to PubMed, human chromosome 22 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 22.
Its subject is documented across 9 Wikipedia language editions.
Gene data
MRTFA- Name
- myocardin related transcription factor A
- Type
- protein-coding
- Position
- 40,410,281–40,636,726 (−)
- Aliases
- BSAC, MAL, MKL, MKL1, MRTF-A
- Ensembl
- ENSG00000196588
- RefSeq RNA
- NM_001282660.2, NM_001282661.3, NM_001282662.3, NM_001318139.2, NM_020831.6
- RefSeq protein
- NP_001269589.1, NP_001269590.2, NP_001269591.2, NP_001305068.1, NP_065882.2
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
myocardin related transcription factor A
- Symbol
- MRTFA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 22:40,410,281-40,636,726
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein MKL1 PDB 2KVU.png
Show 8 more facts
- HomoloGene ID
- 32487
- genetic association
- breast cancer
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/57591
- genomic end
- 40636719
- genomic start
- 40806285
- chromosome
- human chromosome 22
- cytogenetic location
- 22q13.1-q13.2
via Wikidata · CC0
~1 min read
Encyclopedic overview
6 sectionsContents
- Function
- Clinical significance
- Research
- See also
- References
- Further reading
MKL/megakaryoblastic leukemia 1 (also termed MRTFA/myocardin related transcription factor A) is a protein that in humans is encoded by the MKL1 gene.
== Function ==
Excerpted from Wikipedia’s “MRTFA” article, available under the CC BY-SA 4.0 licence.