MRTFA

Also known as BSAC, MAL, MRTF-A, megakaryoblastic leukemia (translocation) 1, MKL, MKL1, myocardin related transcription factor A

MKL/megakaryoblastic leukemia 1 (also termed MRTFA/myocardin related transcription factor A) is a protein that in humans is encoded by the MKL1 gene.

Gene data

MRTFA

Name: myocardin related transcription factor A
Type: protein-coding
Position: 40,410,281–40,636,719 (−)
Aliases: BSAC, MAL, MKL, MKL1, MRTF-A
Ensembl: ENSG00000196588
RefSeq RNA: NM_001282660.2, NM_001282661.3, NM_001282662.3, NM_001318139.2, NM_020831.6
RefSeq protein: NP_001269589.1, NP_001269590.2, NP_001269591.2, NP_001305068.1, NP_065882.2

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].