MKL1

Also known as BSAC, MAL, MRTF-A, megakaryoblastic leukemia (translocation) 1, MKL, myocardin related transcription factor A

gene umano

In the Vinony graph

Vinony's link graph records 111 inbound references to MKL1, and connects out to PubMed, human chromosome 22 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 22.

Vinony links it to 9 Wikipedia language editions.

Gene data

MRTFA

Name: myocardin related transcription factor A
Type: protein-coding
Position: 40,410,281–40,636,726 (−)
Aliases: BSAC, MAL, MKL, MKL1, MRTF-A
Ensembl: ENSG00000196588
RefSeq RNA: NM_001282660.2, NM_001282661.3, NM_001282662.3, NM_001318139.2, NM_020831.6
RefSeq protein: NP_001269589.1, NP_001269590.2, NP_001269591.2, NP_001305068.1, NP_065882.2

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].