MCL1

Also known as BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3

Induced myeloid leukemia cell differentiation protein Mcl-1 is a protein that in humans is encoded by the MCL1 gene.

Gene data

MCL1

Name: MCL1 apoptosis regulator, BCL2 family member
Type: protein-coding
Position: 150,560,895–150,579,738 (−)
Aliases: BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT
Ensembl: ENSG00000143384
RefSeq RNA: NM_001197320.2, NM_021960.5, NM_182763.3
RefSeq protein: NP_001184249.1, NP_068779.1, NP_877495.1

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010].