MCL1
Sign in to saveAlso known as BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3
Induced myeloid leukemia cell differentiation protein Mcl-1 is a protein that in humans is encoded by the MCL1 gene.
Gene data
MCL1- Name
- MCL1 apoptosis regulator, BCL2 family member
- Type
- protein-coding
- Position
- 150,560,895–150,579,738 (−)
- Aliases
- BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT
- Ensembl
- ENSG00000143384
- RefSeq RNA
- NM_001197320.2, NM_021960.5, NM_182763.3
- RefSeq protein
- NP_001184249.1, NP_068779.1, NP_877495.1
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
MCL1 apoptosis regulator, BCL2 family member
- Symbol
- MCL1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:150,560,895-150,579,738
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein MCL1 PDB 2nl9.png
Show 5 more facts
- HomoloGene ID
- 7413
- exact match
- identifiers.org/ncbigene/4170
- genomic end
- 150552066
- genomic start
- 150560895
- cytogenetic location
- 1q21.2
via Wikidata · CC0
~2 min read
Article
7 sectionsContents
- Function
- Clinical significance
- Interactions
- See also
- References
- Further reading
- External links
Induced myeloid leukemia cell differentiation protein Mcl-1 is a protein that in humans is encoded by the MCL1 gene.
== Function ==