seliciclib
Sign in to saveAlso known as (R)-roscovitine, CYC-202, CYC202, R-roscovitine, roscovitine, (2R)-2-{[6-(benzylamino)-9-(1-methylethyl)-9H-purin-2-yl]amino}butan-1-ol, 2-(R)-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine, (2R)-2-((9-(1-methylethyl)-6-((phenylmethyl)amino)-9H-purin-2-yl)amino)-1-butanol
Seliciclib (roscovitine or CYC202) is an experimental drug candidate in the family of pharmacological cyclin-dependent kinase (CDK) inhibitors that inhibit multiple enzyme targets including CDK2, CDK7 and CDK9, which alter the growth phase or state within the cell cycle of treated cells. Seliciclib is being developed by Cyclacel.
Research
1,571 papers- Treatment of Cushing Disease With Pituitary-Targeting Seliciclib.The Journal of clinical endocrinology and metabolism · 2023
- Discovery and development of Seliciclib. How systems biology approaches can lead to better drug performance.Journal of biotechnology · 2015
- Seliciclib in malignancies.Expert opinion on investigational drugs · 2009
- Spatiotemporal control of neutrophil fate to tune inflammation and repair for myocardial infarction therapy.Nature communications · 2024
- Seliciclib (CYC202, R-roscovitine) enhances the antitumor effect of doxorubicin in vivo in a breast cancer xenograft model.International journal of cancer · 2009
via PubMed
Wikidata facts
- Mass
- 354.217
Show 4 more facts
- chemical formula
- C₁₉H₂₆N₆O
- canonical SMILES
- CCC(CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3)N=CN2C(C)C
- isomeric SMILES
- CC[C@H](CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3)N=CN2C(C)C
- World Health Organisation international non-proprietary name
- seliciclib
Sources (2)
via Wikidata · CC0
~4 min read
Article
9 sectionsContents
- Clinical trials and lab tests
- Cancer treatment
- Immunological disorders
- Neurological therapies
- Antiviral effect
- Ovum production
- Renal hypertrophy
- Side effects
- References
{{chembox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 377431079 | ImageFile = Seliciclib structure.svg | ImageClass = skin-invert-image | PIN = (2R)-2-{[6-(Benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol | OtherNames = Roscovitine; CYC202
| Section1=