Proliferating cell nuclear antigen

Protein · UniProt

DNA sliding clamp PCNA

Gene

PCNA

Organism

Homo sapiens (Human)

Length

261 aa

Molecular mass

28,769 Da

Evidence

1: Evidence at protein level

Confers DNA tethering and processivity to DNA polymerases and other proteins (PubMed:24695737, PubMed:24939902, PubMed:35585232). Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of DNA replication by increasing the polymerases' processivity during elongation of the leading strand (PubMed:35585232). Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DD…

• PHASE2ACTIVE_NOT_RECRUITING
  Determinants of Resistance to Endocrine Therapy and a Cyclin-dependent Kinases 4 and 6 (CDK4/6) Inhibitor for HR+ MBCSidney Kimmel Comprehensive Cancer Center at Johns Hopkins · NCT03439735
• COMPLETED
  Expression of miRNa-138 and Cyclin D1 in Oral Mucosa of Patients With Oral Lichen PlanusCairo University · NCT02834520
• COMPLETED
  Treatment Landscape and Real-World Dosing Patterns With CDK4/6 Inhibitors for Breast Cancer in PortugalNovartis Pharmaceuticals · NCT07223476
• PHASE1COMPLETED
  A Study of PRT2527 as Monotherapy and in Combination With Zanubrutinib or Venetoclax in Participants With R/R Hematologic MalignanciesPrelude Therapeutics · NCT05665530
• PHASE3ACTIVE_NOT_RECRUITING
  Assessing a Regorafenib-irinotecan Combination Versus Regorafenib Alone in Metastatic Colorectal Cancer PatientsInstitut du Cancer de Montpellier - Val d'Aurelle · NCT03829462
• COMPLETED
  Treatment of Canadian Men and Pre/Peri/Post-menopausal Women With ER+ Advanced Breast Cancer in the Real-World Setting With Hormone Therapy ± Targeted TherapyNovartis Pharmaceuticals · NCT02753686

via ClinicalTrials.gov

Wikidata facts

Instance of

protein

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