PIDD1

Also known as LRDD, PIDD, p53-induced death domain protein 1

Leucine-rich repeats and death domain containing, also known as LRDD or p53-induced protein with a death domain (PIDD), is a protein which in humans is encoded by the LRDD gene.

Gene data

PIDD1

Name: p53-induced death domain protein 1
Type: protein-coding
Position: 799,179–809,753 (−)
Aliases: LRDD, MRT75, PIDD, altPIDD1
Ensembl: ENSG00000177595
RefSeq RNA: NM_018494.3, NM_145886.4, NM_145887.4, XM_005253005.6, XM_005253006.6
RefSeq protein: NP_665893.2, NP_665894.2, XP_005253062.1, XP_005253063.1, XP_011518511.1

The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010].

Gene Ontology

Biological process

apoptotic process apoptotic process apoptotic process DNA damage response DNA damage response DNA damage response signal transduction signal transduction

Molecular function

endopeptidase activity death receptor binding protein binding

Cellular component

nucleus nucleus nucleus nucleoplasm nucleolus cytoplasm cytoplasm cytoplasm

Pathways

NF-kappa B signaling pathway - Homo sapiens (human)p53 signaling pathway - Homo sapiens (human)Apoptosis - Homo sapiens (human)Generic Transcription Pathway Transcriptional Regulation by TP53 TP53 Regulates Transcription of Cell Death Genes TP53 Regulates Transcription of Caspase Activators and Caspases RNA Polymerase II Transcription Gene expression (Transcription)miRNA regulation of DNA damage response

via MyGene.info

Gene · Ensembl

p53-induced death domain protein 1

Symbol: PIDD1
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:798,938-809,753
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein LRDD PDB 2of5.png

Show 5 more facts

HomoloGene ID: 11220
exact match: identifiers.org/ncbigene/55367
genomic end: 809753
genomic start: 799179
cytogenetic location: 11p15.5

Sources (3)

via Wikidata · CC0

~22 min read

Article

18 sections

Contents

The identification of PIDD1
Death domain
Differential display analysis
Structure of PIDD1
Death fold
Parts and cleavages
Role of chaperones
Multiprotein Complexes Containing PIDD1
PIDDosome
Caps-2-PIDDosome
PCNA-PIDDosome
Relation of PIDD1 to centrosomes
Function
Caspase-2-PIDDosome
PIDD1 and Cancer
Recent Interests on PIDD1
References
Further reading

Leucine-rich repeats and death domain containing, also known as LRDD or p53-induced protein with a death domain (PIDD), is a protein which in humans is encoded by the LRDD gene.

The leucine-rich repeat (LRR), first identified by Patthy, is a domain involved in protein-protein interactions and is present in numerous proteins that serve a variety of cellular roles. Leucine-rich repeats (LRR) proteins in eukaryotic cells are found in the nucleus, cytoplasm, extracellular matrix and plasma membrane.