Also known as MRT34, RAIDD, CASP2 and RIPK1 domain containing adaptor with death domain
Death domain-containing protein CRADD is a protein that in humans is encoded by the CRADD gene.
This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Biological process
Death domain-containing protein CRADD is a protein that in humans is encoded by the CRADD gene.
== Function ==
via MyGene.info
via Wikidata · CC0
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).