DEDD

Also known as CASP8IP1, DEDD1, DEFT, FLDED1, KE05, death effector domain containing

Death effector domain containing protein is a protein that in humans is encoded by the DEDD gene.

Gene data

DEDD

Name: death effector domain containing
Type: protein-coding
Position: 161,120,973–161,133,280 (−)
Aliases: CASP8IP1, DEDD1, DEDPro1, DEFT, FLDED-1, FLDED1, KE05
Ensembl: ENSG00000158796
RefSeq RNA: NM_001039711.2, NM_001039712.2, NM_001330765.2, NM_004216.2, NM_032998.3
RefSeq protein: NP_001034800.1, NP_001034801.1, NP_001317694.1, NP_127491.1, XP_005245656.1

This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].