FADD
Also known as GIG3, MORT1, Fas associated via death domain, IMD90
FAS-associated death domain protein, also called MORT1, is encoded by the FADD gene on the 11q13.3 region of chromosome 11 in humans.
Gene data
FADD- Name
- Fas associated via death domain
- Type
- protein-coding
- Position
- 70,203,295–70,207,395 (+)
- Aliases
- GIG3, IMD90, MORT1
- Ensembl
- ENSG00000168040
- RefSeq RNA
- NM_003824.4
- RefSeq protein
- NP_003815.1
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Article
23 sectionsContents
- Structure
- Functions
- Extrinsic apoptosis
- Necroptosis
- Autophagic cell death
- Development
- Cell cycle regulation
- Lymphocyte proliferation
- Inflammation
- Other
- Regulation
- Subcellular localisation
- c-FLIP
- PKC
- MKRN1
- Roles in inflammatory diseases
- Roles in cancer
- Therapeutic target
- Interactions
- See also
- References
- Further reading
- External links
FAS-associated death domain protein, also called MORT1, is encoded by the FADD gene on the 11q13.3 region of chromosome 11 in humans.
FADD is an adaptor protein that bridges members of the tumor necrosis factor receptor superfamily, such as the Fas-receptor, to procaspases 8 and 10 to form the death-inducing signaling complex (DISC) during apoptosis. As well as its most well known role in apoptosis, FADD has also been seen to play a role in other processes including proliferation, cell cycle regulation and development.