FADD

Also known as GIG3, MORT1, Fas associated via death domain, IMD90

FAS-associated death domain protein, also called MORT1, is encoded by the FADD gene on the 11q13.3 region of chromosome 11 in humans.

Gene data

FADD

Name: Fas associated via death domain
Type: protein-coding
Position: 70,203,295–70,207,395 (+)
Aliases: GIG3, IMD90, MORT1
Ensembl: ENSG00000168040
RefSeq RNA: NM_003824.4
RefSeq protein: NP_003815.1

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008].

Pathways

Apoptosis - Homo sapiens (human)Apoptosis - multiple species - Homo sapiens (human)Necroptosis - Homo sapiens (human)Toll-like receptor signaling pathway - Homo sapiens (human)NOD-like receptor signaling pathway - Homo sapiens (human)RIG-I-like receptor signaling pathway - Homo sapiens (human)IL-17 signaling pathway - Homo sapiens (human)TNF signaling pathway - Homo sapiens (human)Alzheimer disease - Homo sapiens (human)Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

Fas associated via death domain

Symbol: FADD
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:70,203,262-70,220,615
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: FADD based on pdb file 2GF5.gif

Show 6 more facts

HomoloGene ID: 2836
exact match: identifiers.org/ncbigene/8772
genomic end: 70053496
genomic start: 70203296
cytogenetic location: 11q13.3
Commons category: FAS-associated death domain protein

Sources (6)

via Wikidata · CC0

~13 min read

Article

23 sections

Contents

Structure
Functions
Extrinsic apoptosis
Necroptosis
Autophagic cell death
Development
Cell cycle regulation
Lymphocyte proliferation
Inflammation
Other
Regulation
Subcellular localisation
c-FLIP
PKC
MKRN1
Roles in inflammatory diseases
Roles in cancer
Therapeutic target
Interactions
See also
References
Further reading
External links

FAS-associated death domain protein, also called MORT1, is encoded by the FADD gene on the 11q13.3 region of chromosome 11 in humans.

FADD is an adaptor protein that bridges members of the tumor necrosis factor receptor superfamily, such as the Fas-receptor, to procaspases 8 and 10 to form the death-inducing signaling complex (DISC) during apoptosis. As well as its most well known role in apoptosis, FADD has also been seen to play a role in other processes including proliferation, cell cycle regulation and development.