MYD88
Sign in to saveAlso known as MYD88D, myeloid differentiation primary response 88, MYD88, innate immune signal transduction adaptor, MYD88 innate immune signal transduction adaptor, IMD68
Myeloid differentiation primary response 88 (MYD88) is a protein that, in humans, is encoded by the MYD88 gene. originally discovered in the laboratory of Dan A. Liebermann (Lord et al. Oncogene 1990) as a Myeloid differentiation primary response gene.
Gene data
MYD88- Name
- MYD88 innate immune signal transduction adaptor
- Type
- protein-coding
- Position
- 38,138,552–38,143,024 (+)
- Aliases
- IMD68, MYD88D, WM1
- Ensembl
- ENSG00000172936
- RefSeq RNA
- NM_001172566.2, NM_001172567.2, NM_001172568.2, NM_001172569.3, NM_001365876.1
- RefSeq protein
- NP_001166037.2, NP_001166038.2, NP_001166039.2, NP_001166040.2, NP_001352805.1
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
MYD88 innate immune signal transduction adaptor
- Symbol
- MYD88
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:38,138,552-38,143,024
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Toll-like receptor pathways revised.jpg
Show 8 more facts
- HomoloGene ID
- 1849
- genomic start
- 38179969
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/4615
- genomic end
- 38184513
- cytogenetic location
- 3p22.2
- chromosome
- human chromosome 3
- genetic association
- chronic lymphocytic leukemia
via Wikidata · CC0
~4 min read
Encyclopedic overview
6 sectionsContents
- Function
- Interactions
- Gene polymorphisms
- References
- Further reading
- External links
Myeloid differentiation primary response 88 (MYD88) is a protein that, in humans, is encoded by the MYD88 gene. originally discovered in the laboratory of Dan A. Liebermann (Lord et al. Oncogene 1990) as a Myeloid differentiation primary response gene.
== Function ==
Excerpted from Wikipedia’s “MYD88” article, available under the CC BY-SA 4.0 licence.