caveolins
Sign in to saveAlso known as IPR001612, Caveolin
In molecular biology, caveolins are a family of integral membrane proteins that are the principal components of caveolae membranes and involved in receptor-independent endocytosis. Caveolins may act as scaffolding proteins within caveolar membranes by compartmentalizing and concentrating signaling molecules. They also induce positive (inward) membrane curvature by way of oligomerization, and hairpin insertion. Various classes of signaling molecules, including G-protein subunits, receptor and non-receptor tyrosine kinases, endothelial nitric oxide synthase (eNOS), and small GTPases, bind Cav-1
Key facts
- Protein family.Symbol
- Caveolin
- Protein family.Name
- Caveolin
- Protein family.Pfam
- PF01146
- Protein family.InterPro
- IPR001612
- Protein family.PROSITE
- PDOC00930
- Protein.Name
- Caveolin 3
- Protein.HGNCid
- 1529
- Protein.Symbol
- CAV2
- Protein.AltSymbols
- CAV
- Protein.EntrezGene
- 858
- Protein.OMIM
- 601048
- Protein.RefSeq
- NM_001233
- Protein.UniProt
- P51636
- Protein.Chromosome
- 7
- Protein.Arm
- q
- Protein.Band
- 31
via Wikipedia infobox
Research
9,681 papers- Physiological and pathological roles of caveolins in the central nervous system.Trends in neurosciences · 2024
- Editorial: Caveolins in inflammation, infections, and disease.Frontiers in immunology · 2024
- Caveolae and caveolins.Current opinion in cell biology · 1996
- Caveolins and cellular cholesterol balance.Traffic (Copenhagen, Denmark) · 2000
- Caveolins, caveolae, and lipid rafts in cellular transport, signaling, and disease.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2004
via PubMed
~4 min read
Encyclopedic overview
8 sectionsContents
- Structure and expression
- Function
- Role in disease
- Cancer
- Cardiovascular diseases
- Muscular dystrophy
- References
- External links
In molecular biology, caveolins are a family of integral membrane proteins that are the principal components of caveolae membranes and involved in receptor-independent endocytosis. Caveolins may act as scaffolding proteins within caveolar membranes by compartmentalizing and concentrating signaling molecules. They also induce positive (inward) membrane curvature by way of oligomerization, and hairpin insertion. Various classes of signaling molecules, including G-protein subunits, receptor and non-receptor tyrosine kinases, endothelial nitric oxide synthase (eNOS), and small GTPases, bind Cav-1 through its 'caveolin-scaffolding domain'.
The caveolin gene family has three members in vertebrates: CAV1, CAV2, and CAV3, coding for the proteins caveolin-1, caveolin-2, and caveolin-3, respectively. All three members are membrane proteins with similar structure. Caveolin forms oligomers and associates with cholesterol and sphingolipids in certain areas of the cell membrane, leading to the formation of caveolae.
Excerpted from Wikipedia’s “caveolins” article, available under the CC BY-SA 4.0 licence.