CAVIN1

Also known as CAVIN, CGL4, cavin-1, FKSG13, PTRF, polymerase I and transcript release factor, caveolae associated protein 1

Polymerase I and transcript release factor, also known as Cavin1, Cavin-1 or PTRF, is a protein which in humans is encoded by the PTRF gene.

Gene data

CAVIN1

Name: caveolae associated protein 1
Type: protein-coding
Aliases: CAVIN, CGL4, FKSG13, PTRF, cavin-1

This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009].

via MyGene.info

Gene · Ensembl

caveolae associated protein 1

Symbol: CAVIN1
Biotype: Protein coding
Organism: Homo sapiens
Location: 17:42,402,449-42,423,322
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

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HomoloGene ID: 7499
exact match: identifiers.org/ncbigene/284119
genomic end: 42423256
genomic start: 42402449
cytogenetic location: 17q21.2

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Function
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Further reading

Polymerase I and transcript release factor, also known as Cavin1, Cavin-1 or PTRF, is a protein which in humans is encoded by the PTRF gene.

== Function == PTRF (Cavin1) has been shown to be crucial for caveola formation and function. Deformation caveolae promotes the translocation of cavin-1 from caveolae to the nucleus