YWHAZ
Sign in to saveAlso known as 14-3-3-zeta, HEL-S-3, HEL4, KCIP-1, YWHAD, HEL-S-93, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta, POPCHAS
14-3-3 protein zeta/delta (14-3-3ζ) is a protein that in humans is encoded by the YWHAZ gene on chromosome 8. The protein encoded by this gene is a member of the 14-3-3 protein family and a central hub protein for many signal transduction pathways. 14-3-3ζ is a major regulator of apoptotic pathways critical to cell survival and plays a key role in a number of cancers and neurodegenerative diseases.
Gene data
YWHAZ- Name
- tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
- Type
- protein-coding
- Position
- 100,914,526–100,953,397 (−)
- Aliases
- 14-3-3-zeta, HEL-S-3, HEL-S-93, HEL4, KCIP-1, POPCHAS, YWHAD
- Ensembl
- ENSG00000164924
- RefSeq RNA
- NM_001135699.2, NM_001135700.2, NM_001135701.2, NM_001135702.2, NM_003406.4
- RefSeq protein
- NP_001129171.1, NP_001129172.1, NP_001129173.1, NP_001129174.1, NP_003397.1
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
- Symbol
- YWHAZ
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:100,914,526-100,953,397
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~9 min read
Encyclopedic overview
9 sectionsContents
- Structure
- Function
- Antigenic Function
- Signaling regulator
- Clinical Significance
- Interactions
- See also
- References
- Further reading
14-3-3 protein zeta/delta (14-3-3ζ) is a protein that in humans is encoded by the YWHAZ gene on chromosome 8. The protein encoded by this gene is a member of the 14-3-3 protein family and a central hub protein for many signal transduction pathways. 14-3-3ζ is a major regulator of apoptotic pathways critical to cell survival and plays a key role in a number of cancers and neurodegenerative diseases.
== Structure == 14-3-3 proteins generally form ~30 kDa-long homo- or heterodimers. Each of the monomers are composed of 9 antiparallel alpha helices. Four alpha-helices (αC, αE, αG, and αI) form an amphipathic groove that serves as the ligand binding site, which can recognize three types of consensus binding motifs: RXX(pS/pT)XP, RXXX(pS/pT)XP, and (pS/pT)X1-2-COOH (where pS/pT represents phosphorylated serine/threonine). In addition to these primary interactions, the target protein can also bind outside the groove via secondary interactions. In particular, the crystallized structure of 14-3-3ζ forms a cup-shaped dimer when complexed with CBY. The YWHAZ gene encodes two transcript variants which differ in the 5' UTR but produce the same protein.
Excerpted from Wikipedia’s “YWHAZ” article, available under the CC BY-SA 4.0 licence.