TSC complex subunit 2

Protein · UniProt

Tuberin

Gene

TSC2

Organism

Homo sapiens (Human)

Length

1,807 aa

Molecular mass

200,608 Da

Evidence

1: Evidence at protein level

Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of…

• How autophagy controls the intestinal epithelial barrier.Autophagy · 2022
• Buddleoside alleviates nonalcoholic steatohepatitis by targeting the AMPK-TFEB signaling pathway.Autophagy · 2025
• Emerging dimensions of autophagy in melanoma.Autophagy · 2024
• ATM loss disrupts the autophagy-lysosomal pathway.Autophagy · 2021
• Full-coverage regulations of autophagy by ROS: from induction to maturation.Autophagy · 2022

via PubMed

• PHASE3COMPLETED
  Efficacy and Safety of RAD001 in Patients Aged 18 and Over With Angiomyolipoma Associated With Either Tuberous Sclerosis Complex (TSC) or Sporadic Lymphangioleiomyomatosis (LAM)Novartis Pharmaceuticals · NCT00790400
• PHASE3TERMINATED
  Assessment of Adjunctive Cannabidiol Oral Solution (GWP42003-P) in Children With Tuberous Sclerosis Complex (TSC), Dravet Syndrome (DS), or Lennox-Gastaut Syndrome (LGS) Who Experience Inadequately-controlled SeizuresJazz Pharmaceuticals · NCT04485104
• ENROLLING_BY_INVITATION
  Early Check: Expanded Screening in NewbornsRTI International · NCT03655223
• PHASE2UNKNOWN
  Phase 2 Basket Trial of Nab-sirolimus in Patients With Malignant Solid Tumors With Pathogenic Alterations in TSC1/TSC2 Genes (PRECISION 1)Aadi Bioscience, Inc. · NCT05103358

via ClinicalTrials.gov