AXIN1

Also known as AXIN, PPP1R49, axin 1

Axin-1 is a protein that in humans is encoded by the AXIN1 gene.

Gene data

AXIN1

Name: axin 1
Type: protein-coding
Position: 287,440–352,734 (−)
Aliases: AXIN, CMDOH, PPP1R49
Ensembl: ENSG00000103126
RefSeq RNA: NM_003502.4, NM_181050.3, NR_134879.2, XM_011522682.3, XM_011522683.3
RefSeq protein: NP_003493.1, NP_851393.1, XP_011520984.1, XP_011520985.1, XP_011520988.1

This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].