MAP3K1
Sign in to saveAlso known as MAPKKK1, MEKK, MEKK 1, MEKK1, SRXY6, mitogen-activated protein kinase kinase kinase 1
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) is a signal transduction enzyme that in humans is encoded by the autosomal MAP3K1 gene.
Gene data
MAP3K1- Name
- mitogen-activated protein kinase kinase kinase 1
- Type
- protein-coding
- Position
- 56,815,538–56,896,152 (+)
- Aliases
- MAPKKK1, MEKK, MEKK 1, MEKK1, SRXY6
- Ensembl
- ENSG00000095015
- RefSeq RNA
- NM_001445521.1, NM_001445522.1, NM_005921.2, XM_047417218.1, XM_047417219.1
- RefSeq protein
- NP_001432450.1, NP_001432451.1, NP_005912.1, XP_047273174.1, XP_047273175.1
The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
mitogen-activated protein kinase kinase kinase 1
- Symbol
- MAP3K1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:56,815,381-56,896,152
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 8056
- exact match
- identifiers.org/ncbigene/4214
- genomic start
- 56815549
- genomic end
- 56191979
- cytogenetic location
- 5q11.2
via Wikidata · CC0
~5 min read
Article
8 sectionsContents
- Function
- Structure
- Genetic analyses in murine and avian models
- Mechanism of MAPK activation by MAP3K1
- Cancers, other diseases and therapeutic targeting
- Interaction partners
- References
- Further reading
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) is a signal transduction enzyme that in humans is encoded by the autosomal MAP3K1 gene.
== Function ==