MKNK1
Sign in to saveAlso known as MNK1, MAP kinase interacting serine/threonine kinase 1, MAPK interacting serine/threonine kinase 1
MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene.
In the Vinony graph
Within Vinony's link graph, MKNK1 is referenced by 303 other articles, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.
It is catalogued under topics including EC 2.7.11 and Genes on human chromosome 1.
Its subject is documented across 5 Wikipedia language editions.
Gene data
MKNK1- Name
- MAPK interacting serine/threonine kinase 1
- Type
- protein-coding
- Position
- 46,557,407–46,616,850 (−)
- Aliases
- MNK1
- Ensembl
- ENSG00000079277
- RefSeq RNA
- NM_001135553.4, NM_001377337.1, NM_001377338.1, NM_001377341.1, NM_001377342.1
- RefSeq protein
- NP_001129025.2, NP_001364266.1, NP_001364267.1, NP_001364270.1, NP_001364271.1
This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
MAPK interacting serine/threonine kinase 1
- Symbol
- MKNK1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:46,557,407-46,616,850
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein MKNK1 PDB 2hw6.png
Show 8 more facts
- HomoloGene ID
- 37838
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8569
- genomic end
- 47082515
- genomic start
- 46557407
- chromosome
- human chromosome 1
- cytogenetic location
- 1p33
- expressed in
- monocyte
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene.
==Interactions== MKNK1 has been shown to interact with MAPK1 and Eukaryotic translation initiation factor 4 gamma.
Excerpted from Wikipedia’s “MKNK1” article, available under the CC BY-SA 4.0 licence.