PLK4
Sign in to saveAlso known as SAK, STK18, MCCRP2, polo like kinase 4
Serine/threonine-protein kinase PLK4 also known as polo-like kinase 4 is an enzyme that in humans is encoded by the PLK4 gene. The Drosophila homolog is SAK, the C. elegans homolog is zyg-1, and the Xenopus homolog is Plx4.
Gene data
PLK4- Name
- polo like kinase 4
- Type
- protein-coding
- Aliases
- MCCRP2, SAK, STK18
This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
via MyGene.info
Gene · Ensembl
polo like kinase 4
- Symbol
- PLK4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:127,880,890-127,899,224
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein PLK4 PDB 1mby.png
Show 5 more facts
- HomoloGene ID
- 7962
- exact match
- identifiers.org/ncbigene/10733
- genomic end
- 127899224
- genomic start
- 127880893
- cytogenetic location
- 4q28.1
Sources (4)
via Wikidata · CC0
~2 min read
Article
7 sectionsContents
- Function
- Structure
- As a cancer drug target
- Interactions and substrates
- References
- Further reading
- External links
Serine/threonine-protein kinase PLK4 also known as polo-like kinase 4 is an enzyme that in humans is encoded by the PLK4 gene. The Drosophila homolog is SAK, the C. elegans homolog is zyg-1, and the Xenopus homolog is Plx4.
== Function ==