PLK4
Sign in to saveAlso known as SAK, STK18, MCCRP2, polo like kinase 4
Serine/threonine-protein kinase PLK4 also known as polo-like kinase 4 is an enzyme that in humans is encoded by the PLK4 gene. The Drosophila homolog is SAK, the C. elegans homolog is zyg-1, and the Xenopus homolog is Plx4.
Gene data
PLK4- Name
- polo like kinase 4
- Type
- protein-coding
- Position
- 127,880,890–127,899,224 (+)
- Aliases
- MCCRP2, SAK, STK18
- Ensembl
- ENSG00000142731
- RefSeq RNA
- NM_001190799.2, NM_001190801.2, NM_001441357.1, NM_001441358.1, NM_001441359.1
- RefSeq protein
- NP_001177728.1, NP_001177730.1, NP_001428286.1, NP_001428287.1, NP_001428288.1
This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
polo like kinase 4
- Symbol
- PLK4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:127,880,890-127,899,224
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein PLK4 PDB 1mby.png
Show 8 more facts
- HomoloGene ID
- 7962
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10733
- genomic end
- 127899224
- genomic start
- 127880893
- chromosome
- human chromosome 4
- cytogenetic location
- 4q28.1
- expressed in
- rectum
Sources (4)
via Wikidata · CC0
~2 min read
Encyclopedic overview
7 sectionsContents
- Function
- Structure
- As a cancer drug target
- Interactions and substrates
- References
- Further reading
- External links
Serine/threonine-protein kinase PLK4 also known as polo-like kinase 4 is an enzyme that in humans is encoded by the PLK4 gene. The Drosophila homolog is SAK, the C. elegans homolog is zyg-1, and the Xenopus homolog is Plx4.
== Function ==
Excerpted from Wikipedia’s “PLK4” article, available under the CC BY-SA 4.0 licence.