PRKDC
Sign in to saveAlso known as DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350, IMD26
DNA-dependent protein kinase catalytic subunit, also known as DNA-PKcs, is an enzyme that plays a crucial role in repairing DNA double-strand breaks and has a number of other DNA housekeeping functions. In humans it is encoded by the gene designated as PRKDC or XRCC7. DNA-PKcs belongs to the phosphatidylinositol 3-kinase-related kinase protein family. The DNA-Pkcs protein is a serine/threonine protein kinase consisting of a single polypeptide chain of 4,128 amino acids.
Gene data
PRKDC- Name
- protein kinase, DNA-activated, catalytic subunit
- Type
- protein-coding
- Position
- 47,773,108–47,960,182 (−)
- Aliases
- DNA-PKC, DNA-PKcs, DNAPK, DNAPKc, DNPK1, HYRC, HYRC1, IMD26, S473K, XRCC7
- Ensembl
- ENSG00000253729
- RefSeq RNA
- NM_001081640.2, NM_006904.7
- RefSeq protein
- NP_001075109.1, NP_008835.5
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
protein kinase, DNA-activated, catalytic subunit
- Symbol
- PRKDC
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:47,772,970-47,960,182
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 5037
- exact match
- identifiers.org/ncbigene/5591
- genomic end
- 47960178
- genomic start
- 47773111
- cytogenetic location
- 8q11.21
Sources (8)
via Wikidata · CC0
~8 min read
Article
8 sectionsContents
- Function
- Disease
- Apoptosis
- Cancer
- Aging
- Interactions
- Inhibitors
- References
DNA-dependent protein kinase catalytic subunit, also known as DNA-PKcs, is an enzyme that plays a crucial role in repairing DNA double-strand breaks and has a number of other DNA housekeeping functions. In humans it is encoded by the gene designated as PRKDC or XRCC7. DNA-PKcs belongs to the phosphatidylinositol 3-kinase-related kinase protein family. The DNA-Pkcs protein is a serine/threonine protein kinase consisting of a single polypeptide chain of 4,128 amino acids.
== Function ==