WRN

Name

WRN RecQ like helicase

Type

protein-coding

Position

31,033,779–31,176,138 (+)

Aliases

RECQ3, RECQL2, RECQL3

Ensembl

ENSG00000165392

RefSeq RNA

NM_000553.6, XM_011544639.4, XM_011544640.2, XM_054361180.1, XM_054361181.1

RefSeq protein

NP_000544.2, XP_011542941.1, XP_011542942.1, XP_054217155.1, XP_054217156.1

This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017].