MAX

Name

MYC associated transcriptional regulator X

Type

protein-coding

Position

65,006,174–65,102,695 (−)

Aliases

PDMCS, bHLHd4

Ensembl

ENSG00000125952

RefSeq RNA

NM_001271068.2, NM_001271069.2, NM_001320415.2, NM_001407094.1, NM_001407095.1

RefSeq protein

NP_001257997.1, NP_001257998.1, NP_001307344.1, NP_001394023.1, NP_001394024.1

The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].

via MyGene.info

Gene · Ensembl

MYC associated factor X

Symbol

MAX

Biotype

Protein coding

Organism

Homo sapiens

Location

14:65,005,398-65,102,695

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

1an2 max dimer2.png

via Wikidata · CC0