Also known as EDSPD2, complement C1s
protein-coding gene in the species Homo sapiens
Gene data
C1S- Name
- complement C1s
- Type
- protein-coding
- Position
- 6,988,259–7,071,281 (+)
- Aliases
- EDSPD2
- Ensembl
- ENSG00000182326
- RefSeq RNA
- NM_001346850.2, NM_001734.5, NM_201442.4, XM_054373117.1
- RefSeq protein
- NP_001333779.1, NP_001725.1, NP_958850.1, XP_054229092.1
This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009].
Gene Ontology
Biological process
Molecular function
Pathways
Complement and coagulation cascades - Homo sapiens (human)Pertussis - Homo sapiens (human)Staphylococcus aureus infection - Homo sapiens (human)Coronavirus disease - COVID-19 - Homo sapiens (human)Systemic lupus erythematosus - Homo sapiens (human)DiseaseComplement cascadeInitial triggering of complementCreation of C4 and C2 activatorsInnate Immune System
via MyGene.info
Gene · Ensembl
complement C1s
- Symbol
- C1S
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 12:6,988,259-7,071,281
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein C1S PDB 1elv.png
Show 5 more facts
- HomoloGene ID
- 1314
- exact match
- identifiers.org/ncbigene/716
- genomic start
- 7096351
- genomic end
- 7178336
- cytogenetic location
- 12p13.31
Sources (4)
via Wikidata · CC0
Connections
Q180686
Entity
human chromosome 12
Entity
Ensembl genome database project
Entity
Serpin family G member 1
Protein
protein
Entity
International Standard Book Number
Entity
enzyme
Entity
Wikidata
Entity
gene
Entity
immunity
Entity
chromosome
Entity
digital object identifier
Entity
inflammation
Entity
blood coagulation
Entity
bibcode
Entity
human genome
Entity
Q229883
Entity
base pair
Entity
locus
Entity
Medical Subject Headings
Entity