integrin subunit alpha M

Also known as antigen CD11b (p170), Neutrophil adherence receptor, leukocyte adhesion receptor MO1, CR-3 alpha chain, macrophage antigen alpha polypeptide, integrin, alpha M (complement component 3 receptor 3 subunit), CD11 antigen-like family member B, integrin alpha-M

mammalian protein found in Homo sapiens

Protein · UniProt

Integrin alpha-M

Gene: ITGAM
Organism: Homo sapiens (Human)
Length: 1,152 aa
Molecular mass: 127,179 Da
Evidence: 1: Evidence at protein level

Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PubMed:20008295, PubMed:9558116). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen and factor X. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, r…

3D-structureAlternative splicingCalciumCell adhesionCell membraneDirect protein sequencingDisulfide bondGlycoprotein

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Swiss-Prot (reviewed) · via UniProt